Recent research shows that medical illnesses, or the remedies for those illnesses, are much more likely at fault than age group itself. The necessity to urinate is the most common rest disrupter in late life. The NSF poll reported that nearly two in three adults get up to utilize the bathroom at least a few nights weekly. Specific rest disorders, such as restless leg syndrome, periodic limb movements in sleep and sleep apnea or sleep-disordered breathing also are more common with increasing age. In addition, the biological clock, the internal timekeeper, is set earlier in many older adults than in youthful adults, Benloucif explained. This causes an increased tendency to fall earlier and awaken earlier asleep.‘We plan to consult with the FDA relating to the design of future research with plazomicin, which we intend to initiate in the first half of 2013. Our goal is to carry out innovative studies that would evaluate plazomicin’s efficiency in treating significantly ill patients for whom currently available therapies are ineffective.’ Achaogen, Inc. Also announced today that it has begun dosing in the first-in-human medical trial of ACHN-975, a first-in-class LpxC inhibitor that’s being developed for the treating serious infections due to MDR Gram-negative bacteria, including pan-drug resistant Pseudomonas aeruginosa.