Whole-Exome Sequencing We filtered data from whole-exome sequencing in the two index patients by detatching common SNPs. We excluded variants that were found in the NHLBI ESP5400 exome data source and the Yale Center for Genome Evaluation exome database, and we identified uncommon protein-altering variants in each relative. Among these variants, only 18 rare variants had been shared by both index patients , and only 1 1 was found in the linkage interval on chromosome 19. Genotyping resulted in complete cosegregation of the variant with coronary artery disease in all three families. The mutation substituted cysteine for arginine at position 102 of DYRK1B . None of the other 17 variants were found in more than five of the affected associates, and some were also within unaffected family .In the meantime, CQ HealthBeat reports on the political implications of Medicare’s regular premiums.90 per month this year for Part B outpatient insurance. But how do you want to pay 10 % even more for that insurance coverage, or 50 % more? Failing to sign up for Medicare at the right time will set you back – big time. The monthly Part B premium jumps ten % for each complete 12-month period that a senior could have had coverage but didn’t sign up. A mistake could be costly; somebody who fails to enroll for five years would face a 50 % Component B penalty – 10 % for each year of delay. That penalty is definitely permanent, and can translate into thousands in unnecessary life time penalty expenses; a headache no one needs along with already soaring healthcare costs .