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Giancarlo Agnelli, M viagra .D., Harry R. Buller, M.D., Ph.D., Alexander Cohen, M.D., Madelyn Curto, D.V.M., Alexander S. Gallus, M.D., Margot Johnson, M.D., Urszula Masiukiewicz, M.D., Raphael Pak, Ph.D., John Thompson, Ph.D., Gary E. Raskob, Ph.D., and Jeffrey I. Weitz, M.D. For the AMPLIFY Investigators: Oral Apixaban for the Treatment of Acute Venous Thromboembolism Venous thromboembolism, with an annual incidence of just one one to two 2 cases per 1000 persons in the overall population, is the third most common reason behind vascular death after myocardial infarction and stroke.1 Conventional treatment includes a parenteral anticoagulant, such as enoxaparin, for at least 5 days, and warfarin begun during this time period and continuing for at least 3 months.2 Although effective, this regimen presents a challenge because enoxaparin needs daily subcutaneous injections, and warfarin therapy requires coagulation dose and monitoring adjustment.

Medication-refractory tremor was thought as persistent disabling tremor despite at least two trials of a full-dose therapeutic medication, one of which had to add propranolol or primidone.8,9 Doses of medications were stable for 30 days before enrollment and then maintained without adjustment during the study. In each patient, the dominant hand was the most affected extremity and was targeted for treatment severely. Eligibility criteria excluded individuals who had undergone previous stereotactic or cranial surgery treatment or who had additional neurodegenerative circumstances , unstable cardiac conditions, or a coagulopathy.