In some instances, an orthodontist may recommend that an individual have wisdom teeth eliminated if they do not appear to be coming in correctly following the braces have already been removed. The reason? The wisdom teeth may cause the newly straightened teeth to shift and move in the mouth. Wisdom teeth that are not coming in correctly can also become painful, infected, or damage nearby teeth. And speaking of teeth moving and shifting, a very important part of orthodontic treatment is retention, or keeping one’s teeth in their new place.Dr. Yeh found out SUMO and a set of enzymes that remove SUMO known as the SENPs more than 10 years ago. SUMO and SENP are recognized to play important functions in heart development now, neurological cancer and diseases. Related StoriesMelatonin and the circadian rhythm: an interview with Professor Kennaway, University of AdelaideJumping genes: a marker for early cancer diagnosis? An interview with Dr KazazianGenetic carrier screening: an interview with Don Hardison, CEO of Good Start GeneticsDr. Yeh’s group discovered that SENP-2 regulates an integral protein called Computer2 that uses SUMO to improve proteins within cells and turn off gene transcription. During early development, SUMO-modified PC2 binds to the suppressive code of the proteins to turn off many genes that are necessary for development of the heart and various other organs.